Detailed view for LmjF.26.0020

Basic information

TDR Targets ID: 27798
Leishmania major, methylmalonyl-coa epimerase-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4869 | Length (AA): 141 | MW (Da): 15347 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13669   Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 138 1jc4 (A) 10 144 33.00 0 1 1.32 -0.42
5 138 3rmu (A) 45 175 63.00 0 1 1.70795 -0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_130889)

Species Accession Gene Product
Caenorhabditis elegans CELE_D2030.5   Protein MCE-1
Dictyostelium discoideum DDB_G0275181   methylmalonyl coenzyme A racemase
Homo sapiens ENSG00000124370   methylmalonyl CoA epimerase
Leishmania braziliensis LbrM.26.0040   methylmalonyl-coa epimerase-like protein
Leishmania donovani LdBPK_260030.1   methylmalonyl-coa epimerase-like protein
Leishmania infantum LinJ.26.0030   methylmalonyl-coa epimerase-like protein
Leishmania major LmjF.26.0020   methylmalonyl-coa epimerase-like protein
Leishmania mexicana LmxM.26.0020   methylmalonyl-coa epimerase-like protein
Mycobacterium leprae ML1157c   conserved hypothetical protein
Mus musculus ENSMUSG00000033429   methylmalonyl CoA epimerase
Mycobacterium tuberculosis Rv1322A   Conserved protein
Mycobacterium ulcerans MUL_3939   glyoxalase GloA
Mycobacterium ulcerans MUL_2390   hypothetical protein
Schistosoma mansoni Smp_185850   hypothetical protein
Schmidtea mediterranea mk4.000030.13   Methylmalonyl-CoA epimerase, mitochondrial
Trichomonas vaginalis TVAG_083440   conserved hypothetical protein
Trichomonas vaginalis TVAG_097630   Methylmalonyl-CoA epimerase, mitochondrial precursor, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.26.0020 (Leishmania major), methylmalonyl-coa epimerase-like protein
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